Job Description:
- Pay: $40-51.72/hr.
- 11-month assignment with possibility for extension or conversion based on performance and budget.
- Prepares and optimizes pre-clinical drug formulations using appropriate technology and scientific principles for in vivo PK, Pharmacology, and safety studies
- Conducts limited screening of known excipients, pH adjustment, etc, and chemical/physical stability check for program compounds. Prepares cassette dosing solutions for PK screening.
- Conducts experiments and analyzes/shares data to support project progression using analytical instrumentation (HPLC, Mass Spec) to assess formulation stability and chemical stability
- Accurately records formulation experiments/protocols in an e-notebook
- Prepares/shares formulation protocols, technical reports, presentations, and regulatory documents as necessary
- Ensures formulations meet IUCUC guidelines and industry standards in coordination with in vivo study director
- Understanding and ability to implement good laboratory practices, particularly in handling preclinical pharmaceutical small molecule API for neuroscience, immunology, and oncology indications
- Collaborates with a Global Chemistry manager, cross-functional research project teams, CROs, the Comparative Medicine group, and Pharmaceutical Science colleagues to provide project specific formulations and formulations strategies for in vivo studies (PK, efficacy, tox)
- Bachelor’s degree in a chemistry or pharmaceutical science, or equivalent with 5+ years of experience, or Master's degree with 3+ years of experience in formulating small molecule APIs
- Broad knowledge of acceptable excipients and equipment/instruments widely used in pre-clinical formulation preparation
- Demonstrates technical knowledge of formulations and pharmaceutics of small molecule APIs including:
- Solubilizing/solution formulations
- Solid/suspension formulations
- Well-versed in analytical instrumentation (HPLC, Mass Spec) to assess:
- Formulation stability (physical)
- Chemical stability
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