Details for the position are as follows:
- 6 month contract to start with the possibility of extension or conversion depending on performance and budget.
- Rate: $100-133hr
- Location: Cambridge, MA – this is a Hybrid position
- Define and execute translational and biomarker plans for Blueprint’s preclinical and clinical-stage allergy and immunology programs with a focus on mechanism of action, target engagement, establishment of PK/PD/efficacy relationships, patient selection strategies and understanding mechanisms of intrinsic and acquired resistance.
- Ensure that discovery, pre-clinical and clinical biomarker plans are developed and implemented efficiently and aligned with the strategic needs of the program.
- Perform and/or oversee experimental design, lab-based research, data analysis, data integration and data storage. Independently conduct, optimize, and proactively troubleshoot assays both in-house and with CRO.
- Manage external biomarker analysis at specialty CROs including experimental design, validation, qualification, budgeting, timelines, and oversight of quality and execution during trial conduct.
- Represent Translational Medicine within project/program teams; share scientific and strategic perspectives, generate data to support team needs, and meet project/program milestones for TM responsibilities.
- Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions, abstracts, and publications.
- Analyze, interpret, and present integrated scientific results and implications for program strategy to internal and external stakeholders.
- Effectively collaborate across internal functions including discovery, translational, clinical pharmacology, clinical development, data management to ensure successful execution in the clinic.
- Clearly communicate translational strategies, timelines, dependencies, risks, and mitigations to team members.
- Evaluate new technologies and partner with external collaborators to enable exploratory biomarkers
- Regularly present research to Translational Medicine and integrated project teams highlighting implications and opportunities for broader program.
- PhD in Molecular biology, cell biology, with focus on allergy and/or Immunology research, or related discipline
- Relevant post-doctoral training and/or 4-6 years of relevant experience in a biopharmaceutical research setting
- Minimum of 2 years translational, clinical research experience
- Direct research experience in Allergy, Asthma, Anaphylaxis and/or related diseases
- Strong interpersonal and communication skills, with a passion for participating in a fast-paced environment characterized by challenging and rigorous science, and innovative thinking
- Hands-on experience with molecular and cellular assay development, validation, and data analysis is preferred (e.g., PCR, NGS, Western blotting).
- Handson experience in multiplex IHC/IF and cytokine assay development and analysis.
- Extensive experience with state-of-the-art assays and standard analytical software tools (e.g., Excel, Prism, etc.).
- Familiarity with PK/PD/efficacy relationships and delivering PD readouts.