Details:
Requirements:
Position Summary:
- Pay for this position is 41.00 to 45.52 hourly depending on experience.
- This position is a one year contract with the possibility of extension or conversion to permanent.
- Location: South San Francisco, CA
Requirements:
- B.S., M.S., or equivalent degree in Biochemistry, Molecular Biology, Chemical Biology, or a related discipline with relevant lab-based experience.
- Hands-on experience with in vitro display technologies, particularly mRNA display and/or phage display (including phage propagation and selection).
Position Summary:
- The successful candidate will contribute to the identification of Client macrocyclic peptides using in vitro selection platforms and will play a key role in assay development, high-throughput screening, and data analysis for early drug discovery programs.
- Conduct in vitro selection campaigns using mRNA and/or phage display technologies to Client active macrocyclic peptides targeting high-priority therapeutic proteins.
- Handle phage libraries, including amplification, titration, panning, and rescue procedures.
- Design and execute ELISA-based binding assays for hit validation and screening.
- Utilize laboratory automation and high-throughput screening (HTS) techniques to enable efficient assay setup, sample processing, and reagent preparation.
- Analyze next-generation sequencing (NGS) results using internal bioinformatics tools to identify early hits and guide selection campaign progression.
- Test the incorporation and expression of non-canonical amino acid monomers to enhance library diversity through genetic code expansion.
- Maintain and manage complex reagent inventories used across multiple preclinical discovery platforms.